A magnetic-directed micro-particle with near-IR light triggered guest-release property

Abstract

In this study, guest carriers, composed of magnetic-directed hydrogel particles with near-infrared (NIR)-light-triggered guest-release properties, are prepared via the one-pot method. The gel particles contain photostable NIR-responsive polypyrrole nanoparticles with temperature-sensitive poly(N-isopropyl acrylamide), the combination of which can induce the accelerated release of encapsulated drugs by 337% upon 5 minutes of NIR light irradiation based on the release profile of NRMG-1 at 10–15 min. Additionally, with magnetic iron oxide particles crosslinking the polyvinyl alcohol frames, these gel particles can form a physical barrier that decreases the release rate by 20% under an external magnetic field over 24 h. The magnetic iron oxide particles also enable the gel particles to reach their target destination without extra drug losses.