September 2020

Journal

Phenyleneethynylene trimer-based rigid-flexible [2+2] macrocycles for nucleic acid labelling in live cells

By:
Ho moon, Joong; Manandhar, Prakash; Torabi, Hooman; Rohman, Md; Mathivathanan, Logesh; Hung lee, Ka; Irle, Stephan
Journal Name:
Chemical Communications
Page Number:
5930-5933
Volume:
55
Issue Number:
42
Publication Date:
September 28, 2020
View DOI Listing:
https://doi.org/10.1039/C9CC02162K

Abstract

Fluorescent macromolecules were developed for intracellular labeling in live cells. Coupling rigid rod phenyleneethynylene trimers with flexible amphiphilic diamines via the imine-bond formation chemistry yielded rigid–flexible [2+2] macromolecules showing nucleic acid selectivity and nontoxicity in live cells.


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